I used four Saitek Flight Instrument Panels with X Plane 11 in Windows 10 with all regular updates in 2018-2021.
The following information may not be up to date (I did it in 2018):
it was important first to install the driver from Logitech (Flight_Instrument_Panel_x64_Drivers_8.0.150.0.exe) and then to install the X-Plane Plug-in (XPlane_Plugin_x64_Software.exe, also from Logitech). Unfortunately the old link https://support.logitech.com/en_us... is not active any more.