Yes, as long as the contact surface of the cooler to the CPU is not made of aluminium. Since liquid metal is conductive, it is a little trickier to apply, but in my personal opinion it is not more difficult. It is best to cover everything around the CPU during application in case something should go wrong. According to various sources, liquid metal slightly corrodes the surface of the CPU's headspreaders, but this is only an optical problem.
but this should only be visually disturbing.