The AF-S Nikkor 200-500mm f/5.6E ED VR lens is compatible with the Nikon D5600, which is similar to the D5600. However, to confirm specific compatibility with the Nikon 5600, it is important to check whether the '5600' model is an existing Nikon model, as current models include the D5600. If you are referring to the D5600, then yes, this lens is compatible with that model.