The two-volume set LNAI 9692 and LNAI 9693 includes the peer-reviewed proceedings of the 15th International Conference on Artificial Intelligence and Soft Computing (ICAISC 2016), which took place in June 2016 in Zakopane, Poland. These volumes contain 134 revised full texts carefully selected from 343 submitted papers. The first volume covers topics such as neural networks and their applications, fuzzy systems, evolutionary algorithms, agent systems, and pattern classification. The second volume focuses on areas such as bioinformatics, biometrics, medical applications, data analysis, the role of artificial intelligence in modeling and simulation, and the interface between visual information coding and machine learning.