The textbook "Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin's Neuroendocrine System" offers a comprehensive analysis of the role of the skin as a neuroendocrine organ that regulates both local and global homeostasis. The skin, being the largest organ of the body, serves as an interface to the external environment and is capable of detecting and responding to a variety of stressors, including UV radiation. The book highlights the complex interactions between epidermal and dermal cells as well as central regulatory systems and their significance in maintaining peripheral homeostasis. It describes various biologically active products and their production in the skin, which are stimulated by different factors. These insights are of great importance to professionals in the fields of medicine and nursing, as they enhance the understanding of skin functions and their impact on health.