Question about ROG STRIX X670E-A GAMING WIFI - 563872

You can fully utilise both PCIe Gen5 m.2 and both Gen4 m.2 slots without it having any effect on the PCIe Gen5 x16 or the SATA ports. Only the PCIe Gen4 x16 slot of the chipset runs only with x4, but this is quite normal.
The X670E boards, which have two PCIe Gen5 x16 slots, sometimes have very slanted partitions.

This is one of the reasons why I chose this board (by the way, the ASUS X670E-F Gaming is the same board in a different colour and with a very slight difference in the USB ports).